Tree Grand Canyon

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What are good road trip options from San Francisco?

Me and my 2 friends are trying to plan about a 2 week long road trip. we can't decide whether to go North or South, and want some advice on where to go and options.
This is what we have thought of

North:
Crater lake
mt. shasta
mt. hood
portland
Seatle

South:
Yosemite
Joshua Tree
Grand Canyon

If the "2 weeks" are in the summer. Then head north, as it's cooler for the most part. Late fall thru spring, then the desert regions to the south is nice. The Palm Springs area (Joshua Tree) is interesting. If you must see Grand Canyon, then Las Vegas is certainly a must.
There is wilderness in both regions, if you are planning to camp / pack, then you should consider the climate prior to leaving.

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